Two recent reports purport to show that PXD modifies the activity of both normal lymphocytes and leukaemic cells, with the suggestion that it might have therapeutic potential in the treatment of certain blood-related disorders including leukaemia and certain autoimmune diseases. The first report is as follows. Phenoxodiol, an anticancer isoflavene, induces immunomodulatory effects in vitro [...]
From the outset, prostate cancer has been a highly promising target for phenoxodiol (PXD), based on a range of mechanisms of action that have particular application in this form of cancer. The following is divided into four parts. The first part is a background look at prostate cancer, in particular those aspects of the disease [...]
Triphendiol is the second anti-cancer drug from the Novogen isoflavonoid drug pipeline to enter the clinic. Triphendiol (previously known as NV-196) is a modification of the phenoxodiol skeleton. Phenoxodiol Triphendiol Being closely related structurally, the two drugs not surprisingly display many features in common. Like phenoxodiol, triphendiol displays the following characteristics: it is orally available [...]
NV-128 is the third drug to emerge from the Novogen anti-cancer pipeline to be ear-marked for development. NV-128 was selected from several hundred candidate compounds for further development, in part because it demonstrates considerably greater anti-cancer potency than phenoxodiol and triphendiol, and in part because its mechanism of action appears to differ substantially from that [...]
A Twisted Tale By Way of Background Phenoxodiol owes its discovery to a misguided belief in the early 1990s (and unfortunately still present in some quarters today) that dietary isoflavones are bad for us….that they will cause female babies to develop reproductive abnormalities, that they are behind the falling sperm counts in modern man, and [...]
This is for those people who are new to the story or for those who still struggling with the concept of what Novogen and Marshall Edwards are all about. The story has its roots in the very beginnings of life … in particular, a crucial step that enabled simple, single-cell organisms to develop into higher [...]